We always hope to grow the team with scientists and students who share our passion for high resolution microscopy of individual molecules, preparative mass spectrometry, and instrumentation development. Please be in touch to discuss opportunities in detail.
Postdoctoral research projects can range over the entire spectrum of our scientific portfolio.
We aim to support applicants in preparing a proposal to postgraduate research funding (e.g. ERC-Marie Curie Program, Humboldt program).
Please contact us with a short cv if you have interest in joining us as a postdoc.
DPhil (PhD) opportunities
We can offer a number of exciting projects for DPhil (PhD) studies.
(1) Cryo-TEM imaging of mass selected proteins. (Research Page)
Cryogenic electron microscopy (cryo-EM) is emerging as the dominating method for structure determination of proteins. However, the sample preparation is based on plunge freezing proteins in solution into thin ice layers, which limits contrast and scope of the sample preparation method as many proteins are not compatible with this preparation method. We are developing and applying and alternative method of cryo-EM sample preparation, which is based on preparative mass spectrometry to prepare samples without ice directly in vacuum.
(2) Imaging biopolymers by scanning probe microscopy.
Scanning probe microscope (STM: scanning tunneling microscopy, AFM: atomic force microscopy) can resolve molecular structure at the atomic level. We investigate molecules of complex structure and conformation adsorbed at a surface, brought there with ES-IBD. Important goal are the sequencing of peptides and glycans as well as the atomically resolved imaging of large molecules by non-contact AFM.
(3) Chemical reactions triggered by hyperthermal collisions of molecules and surfaces. (Research Page)
Energy is needed to make chemical reactions proceed. Usually this energy is supplied from thermal energy, sometimes from light or other excitations. The collision of ions with surfaces at hyperthermal energy represents a unique way of supplying that energy. In this project we use the unique capability of Electrospray ion beam deposition to tune the collision energy in the range between 1eV and several 100eV to trigger chemical reactions which otherwise cannot be observed. We will investigate the mechanochemical mechanism that proceeds in this type of reaction and explore its possibility to covalently modify surfaces with complex molecules. (Fast Molecular Compression by a Hyperthermal Collision Gives Bond-Selective Mechanochemistry. Phys. Rev. Lett. 126 (5), 056001 (2021) )
(4) Development of novel electrospray ion beam deposition (ES-IBD) instrumentation
Electrospray ion beam deposition (ES-IBD) is the deposition of mass-selected molecular ion on surfaces in vacuum, whereby the energy of the molecular ion beam can be controlled. We develop a novel instrument based on advanced ion optics, which will allow us high selectivity (mass, mobility(shape)) while also have high beam intensity and control over the ionisation process.
Further information about the current admission: Graduate open day of the Department of Chemistry
There are several routes towords funding for A DPhil position; details below.
Department of Chemistry - Information on the postgraduate studies program
University of Oxford - Information on DPhil in Chemistry
University of Oxford: Doctoral Training Centres
Part II / Master thesis
We offer several Part II positions every year. Please be in touch to inquire for project details or a lab visit.
The options lecture Molecular Surface Science offers an ideal preparation.
group leader and PI
Tel: +44(0)1865-2 72620
Office: CRL ground floor office 6
Since 2017 Prof. of Physical Chemistry, University of Oxford
Tutorial Fellow of Wadham College.
2007-2017 Group leader, Electrospray Ion Beam Deposition Lab, Department
Max-Planck-Institute for Solid State Research, Stuttgart.
2007 Dr. sc. (PhD) in Physics, École Polytechnique Fédérale de Lausanne (EPFL).
2004 –2007 PhD student, Max-Planck-Institute for Solid State Research
1997-2003 Study of Physics at the University of Augsburg, ETH Zürich, TU München
Paul Fremdling (PhD)
Paul has joined our group in February 2018 as a doctoral student. Trained as an analytical chemist in an integrated French-German program at the Université de Strasbourg and the Technische Universtät Dresden, he is now developing new preparative Mass Spectrometry instrumentation focused on high-efficieny ion transfer from source to sample.
Tim Esser (Postdoc)
||During his doctoral studies at the University of Leipzig, Tim planned, built and characterized a novel cryogenic mass spectrometer for spectroscopy of single nanoparticles to explore size dependence of optical and chemical properties. He joined the group in 2019 and is now working on an interface between (native) preparative mass spectrometry and cryo electron microscopy.
Part II students
Jovana Pepic, Michael Freeman, Thomas Auckland
PAST GROUP MEMBERS
Joseph Gault (Postdoc 2018-2020)
Mark Agasid (Postdoc 2021)
Ikhlaas Pokun (Part-II student, 2018/19)
Dhiren De Silva (Part-II student, 2019/20)
Samuel Britton (Part-II student, 2019/20)
Alex Butler (Part-II student, 2020/21)
Alex Eacott (Part-II student, 2020/21)
Links displayed here lead to external pages of the past group member. While we check for them being relevant and appropriate, those are external links, and the material is not our responsibility. Please contact us to request contact pst members.