We have modified a commercial mass spectrometer for the native deposition of large, native protein complexes. To this end, we added a landing module, and modified the vacuum system to increase transmission. The new instrument has a narrow beam energy distribution for gentle deposition. It can produce mass-selected samples for AFM and TEM from native protein ion beams. With the instrument, we demonstrate the non-covalent protein complex ADH retains enzymatic activity after deposition and rehydration.

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